Can you caulk over caulk? Yes, but it depends on the materials and preparation. Silicone caulk adheres poorly to existing caulk, so it’s best to remove old caulk before applying silicone. Latex or acrylic caulk can be applied over existing caulk, but it may not bond as well. To ensure a strong bond, clean and dry the surface, remove any loose caulk, and apply a layer of caulk-compatible primer before caulking.