Copper plumbing replacement costs vary depending on factors such as labor rates, pipe diameter, complexity of the work, and the amount of copper piping being replaced. On average, replacing copper plumbing costs $150-$500 per foot for labor and materials. For a typical house with 50-75 feet of copper piping, the total cost can range from $7,500-$37,500. It’s essential to contact licensed plumbing professionals for accurate estimates based on your specific needs and location.