Diatomaceous earth (DE), a powdery substance composed of fossilized algae, is widely used as a natural spider control agent. Its sharp, microscopic edges cause dehydration and injury to spiders’ exoskeletons, resulting in death. While DE is generally safe for humans and pets when handled properly, it can irritate the respiratory system if inhaled. Its effectiveness against spiders is supported by anecdotal evidence and scientific studies, indicating its potential as a non-toxic and environmentally friendly control method.