Drill and fill insulation cost varies depending on the size of the area being insulated, the type of insulation used, and the labor costs in your region. Typically, drill and fill insulation costs between $0.50 and $2.00 per square foot, with higher costs for more specialized insulation materials. Factors that can increase the cost include the accessibility of the area being insulated, the need for specialized equipment, and the removal and disposal of existing insulation.