To eliminate fire ants in your home, identify areas of infestation and remove any food sources. Vacuum or sweep up ants and eggs, and use a strong insecticide labeled for fire ant control around entry points and affected areas. Seal up cracks and gaps where ants may enter, and keep your yard clear of debris and vegetation that provide hiding spots. For severe infestations, consider contacting a professional pest control company for targeted treatment and ongoing prevention strategies.