Polyurethane allergic reactions are triggered by contact with isocyanate-containing polyurethane, a prevalent material used in various products. Allergic contact dermatitis, mediated by IgE, T-cells, and histamine, is the primary manifestation. Healthcare workers and manufacturing personnel face occupational exposure risks. Consumer products like clothing, mattresses, and upholstery often contain polyurethane. Diagnosis involves patch testing, while management includes avoidance and treatment with antihistamines or topical corticosteroids. Understanding polyurethane allergy is crucial for healthcare professionals and individuals prone to it to minimize exposure and manage symptoms effectively.