Silicone caulk excels in durability and moisture resistance, making it ideal for sealing joints, windows, and doors. Its flexibility prevents cracking during movement, while its high temperature tolerance withstands extreme conditions. In contrast, acrylic caulk is water-based, paintable, and less expensive. It’s suitable for indoor applications, sealing gaps in walls and trims, but may not be as durable or moisture-resistant as silicone.